-
oa A Highly Active Palladium(I) Dimer for Pharmaceutical Applications
[Pd(μ-Br)(tBu3P)]2 AS A PRACTICAL CROSS-COUPLING CATALYST
- Source: Platinum Metals Review, Volume 53, Issue 4, Oct 2009, p. 183 - 188
-
- 01 Jan 2009
Abstract
The Pd(I) dimer [Pd(μ-Br)(tBu3P)]2is one of the best third-generation cross-coupling catalystsfor carbon–carbon and carbon–heteroatom coupling reactions. Information on its characterisation and handling are presented, including its decomposition mechanism in the presence of oxygen. The catalytic activity of [Pd(μ-Br)(tBu3P)]2is higher than either (tBu3P)Pd(0) or the in situ generated catalyst system based on Pd2(dba)3with tBu3P. Examples of suitable reactions for which the Pd(I) dimer offers superior performance are given.
© Johnson Matthey