Metal-Ligand Exchange Kinetics in Platinum and Ruthenium Complexes: SIGNIFICANCE FOR EFFECTIVENESS AS ANTICANCER DRUGS

By Jan Reedijk

doi:10.1595/147106708X255987

ISSN: 0032-1400

oa Metal-Ligand Exchange Kinetics in Platinum and Ruthenium Complexes

SIGNIFICANCE FOR EFFECTIVENESS AS ANTICANCER DRUGS
By By Jan Reedijk¹
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Affiliations: ¹ Leiden Institute of ChemistryPO Box 9502, 2300 RA, LeidenThe Netherlands
Source: Platinum Metals Review, Volume 52, Issue 1, Jan 2008, p. 2 - 11
DOI: https://doi.org/10.1595/147106708X255987
- Published online: 01 Jan 2008

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Abstract

Metal coordination compounds with ‘slow’metal-ligand exchange rates, comparable to those of cell division processes, often appear to be highly active in killing cancer cell lines. This is particularly marked in platinum and ruthenium complexes. Classical examples such as cisplatin, as well as very recent examples from the author’s and other work, will be discussed in detail, and in the context of the current knowledge of the mechanism of antitumour action. It is shown that even though much is known about the molecular mechanism of action of cisplatin, many challenging questions are left for future research. For the ruthenium anticancer drugs molecular mechanistic studies are only at the beginning. Mechanistic studies on both platinum and ruthenium compounds have, however, opened many new avenues of research that may lead to the design of completely new drugs.

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Metal-Ligand Exchange Kinetics in Platinum and Ruthenium Complexes

Platinum Metals Review 52, 2 (2008); https://doi.org/10.1595/147106708X255987

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oa Metal-Ligand Exchange Kinetics in Platinum and Ruthenium Complexes

SIGNIFICANCE FOR EFFECTIVENESS AS ANTICANCER DRUGS

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