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1887
Volume 15, Issue 2
  • ISSN: 0032-1400

Abstract

Certain complexes of the platinum group metals exhibit interesting biological effects. At low concentrations some are effective bacteriocides; others stop cell division and force bacteria to grow into long filaments. These complexes can also induce destruction of lysogenic bacteria. Most important, perhaps, some of these complexes are very potent anti-tumour agents against a broad spectrum of tumours, and may shortly be used for cancer chemotherapy in humans.

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1971-01-01
2024-06-22
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References

  1. Rosenberg B., VanCamp L., and Krigas T. Nature, 1965, 205, 698 [Google Scholar]
  2. Rosenberg B., Renshaw E., VanCamp L., Hartwick J., and Drobnik J. J. Bact., 1967, 93, 716 [Google Scholar]
  3. Rosenberg B., VanCamp L., Grimley E., and Thomson A. J. J. Biol. Chem., 1967, 242, 1347 [Google Scholar]
  4. Bromfield R. J., Dainty R. H., Gillard R. D., and Heaton B. T. Nature, 1969, 223, 735 [Google Scholar]
  5. Gale G. R., Howle J. A., and Smith A. B. Arch. Int. Pharmacodyn., 1971, in press [Google Scholar]
  6. Reslova S. International Symposium “Bacterial, Viral and Anti-Tumour Activities of Platinum Compounds”, Mich. State Univ., Sept. 1970 [Google Scholar]
  7. Rosenberg B., VanCamp L., Trosko J. E., and Mansour V. H. Nature, 1969, 222, 385 [Google Scholar]
  8. Rosenberg B., and VanCamp L. Cancer Res., 1970, 30, 1799 [Google Scholar]
  9. VanCamp L. 1970, personal communication
  10. Kociba R. J., Sleight S. D., and Rosenberg B. Cancer Chemother. Rep., 1970, 54, 325 [Google Scholar]
  11. Connors T. A., and Haddow A. International Symposium “Bacterial, Viral and Anti-Tumour Activities of Platinum Compounds”, Mich. State Univ., Sept. 1970 [Google Scholar]
  12. Welsch C. ibid.
  13. Hinz R. ibid.
  14. Venditti J. ibid.
  15. Toth-Allen J., and Rosenberg B. 1971, submitted for publication
  16. Harder H. C., and Rosenberg B. Int. J. Cancer, 1970, 6, 207 [Google Scholar]
  17. Howle J. A., and Gale G. R. Biochem. Pharmacol., 1971, in press [Google Scholar]
  18. Drobnik J. 1970, personal communication
  19. Drobnik J., Krekulova A., and Kubelkova A. 1971
  20. Huebner R. J., and Todaro G. J. Proc. Natl. Acad. Sci. U.S., 1969, 64, 1087 [Google Scholar]
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  • Article Type: Research Article
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