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Volume 17, Issue 1
  • ISSN: 0032-1400


A wide variety of platinum(II) complexes have been synthesised and tested for anti-tumour activity resulting in the identification of additional potentially active anti-tumour drugs. Several structural features have been shown to be necessary for a complex to show activity. This article follows up the article by Professor Barnett Rosenberg in the April 1971 issue.


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  1. Rosenberg B., Van Camp L., Trosko J. E., and Mansour V. H. Nature, 1969, 222, 385 [Google Scholar]
  2. Rosenberg B., and Van Camp L. Cancer Res., 1970, 30, 1799 [Google Scholar]
  3. Rosenberg B. Platinum Metals Rev., 1971, 15, (2) 42 [Google Scholar]
  4. Cleare M. J., and Hoeschele J. D. Bioinorg. Chem., in press [Google Scholar]
  5. Connors T. A., Jones M., Ross W. C. J., Braddock P. D., Khokhar A. R., and Tobe M. L. Chem. Bid. Interactions, in press [Google Scholar]
  6. Cancer Chemotherapy National Service Centre Protocols, Cancer Chemotherapy Reports, 1962, No. 25 [Google Scholar]
  7. King H. J. S. J. Chem. Soc., 1938, 1338 [Google Scholar]
  8. Dhara S. C. Indian J. Chem., 1970, 8, 143 [Google Scholar]
  9. Tucker M. A., Colvin C. B., and Martin D. S. Inorg. Chem., 1964, 3, 1373 [Google Scholar]
  10. Colvin C. B., Grunther R. G., Hunter L. D., McLean J. A., Tucker M. A., and Martin D. S. Inorg. Chim. Acta, 1968, 2, 487 [Google Scholar]
  11. Hoeschele J. D., Van Camp L., Cleare M. J., and Rosenberg B.
  12. Harder H. C., and Rosenberg B. Int. J. Cancer, 1970, 6, 207 [Google Scholar]
  13. Howie J. A., and Gale G. R. Biochem. Pharmacol., 1970, 19, 2757 [Google Scholar]
  14. Roberts J. J., and Pascoe J. M. Nature, 1972, 235, 282 [Google Scholar]
  15. Reishus J. W., and Martin D. S. J. Am. Chem. Soc., 1961, 83, 2457 [Google Scholar]
  16. Banerjea D., Basolo F., and Pearson R. G. J. Am. Chem. Soc., 1957, 79, 4055 [Google Scholar]
  17. Basolo F., Gray H. B., and Pearson R. G. J. Am. Chem. Soc., 1960, 82, 4200 [Google Scholar]
  18. Cattalini L., Prog, in Inorg. Chem., ed. and Edwards J. O. 1970, 13, 263 and references therein [Google Scholar]
  19. Rosenberg B., and Davidson J. U.S. Patent applied for) [Google Scholar]
  20. Gale G. R., Howie J. A., and Walker E. M. Cancer Res., 1971, 31, 950 [Google Scholar]
  21. Rosenberg B., Van Camp L., and Peresie H.
  22. Connors T. A.
  23. Basolo F., and Pearson R. G. New York, 1967, p. 355 and references therein
  24. Gale G. R., Howie J. A., and Smith A. B. Proc. Soc. Exp. Biol. Med., 1970, 135, (3) 690 [Google Scholar]

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  • Article Type: Research Article
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