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1887
Volume 23, Issue 3
  • ISSN: 0032-1400

Abstract

A platinum compound, cis-diamminedichloroplatinum (II)—known as cisplatin—has recently received the approval of the governments of the United States of America and the United Kingdom for chemotherapy of specific cancers. This paper gives a brief account of the discovery of the physiological activity of certain platinum co-ordination complexes by Professor Barnett Rosenberg and his colleagues, and of the clinical development and testing that has now resulted in its acceptance. While work is continuing to develop superior drugs of this type, and to find a better understanding of their modes of action, it is anticipated that this first generation metal anti-cancer drug will be used for many years to come.

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1979-01-01
2024-02-27
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References

  1. Rosenberg B., Van Camp L., Trosko J. E., and Mansour V. H. Nature, 1969, 222, 385 [Google Scholar]
  2. Rosenberg B., Van Camp L., and Krigas T. Nature, 1965, 205, (4972), 698 [Google Scholar]
  3. Rosenberg B., Van Camp L., Grimley E. B., and Thomson A. J. J. Biol. Chem., 1967, 242, (6), 1347 [Google Scholar]
  4. Renshaw E., and Thomson A. J. J. Bacteriol., 1967, 94, (6), 1915 [Google Scholar]
  5. Rosenberg B., and Van Camp L. Cancer Res., 1970, 30, (6), 1799 [Google Scholar]
  6. 6 Connors T. A., and Roberts J. J. 1973. ed, Springer Verlag, Berlin, Heidelberg, New York, 1974
  7. Chary K. K., Higby D. J., and Henderson E. S. J. Clin. Hematol. Oncol., 1977, 7, (2), 633 [Google Scholar]
  8. Hayes D. M., Cvitkovic E., Golbey R. B., Scheiner E., Helson L., and Krafoff I. E. Cancer, 1977, 39, (4), 1372 [Google Scholar]
  9. 9The Third International Symposium on Platinum Co-ordination Complexes in Cancer Chemotherapy, J. Clin. Hematol. Oncol.,Wadley Institute Publication, 1977, 7, (2) [Google Scholar]
  10. Samuels M. L., Holoye P. Y., and Johnson D. E. Cancer, 1975, 36, (2), 318 [Google Scholar]
  11. Einhorn L. H. 11 Washington 1978. To be published
  12. Wiltshaw E., and Kroner T. Cancer Treat. Rep., 1976, 60, (1), 55 [Google Scholar]
  13. Bruckner H. W., Cohen C. J., Gusberg S. B., Wallach R. C., Kabakow B., Greenspan E. N., and Holland J. F. Proc. Am. Soc. Clin. Oncol., published in Proc. Am. Assoc. Cancer Res., 1976, 17, 287 [Google Scholar]
  14. Wiltshaw E., and Bruckner H. W. 14 Washington, 1978
  15. Lange R. C., Spencer R. P., and Harder H. C. J. Nucl. Med., 1972, 13, (5), 328 [Google Scholar]
  16. Lange R. C., Spencer R. P., and Harder H. C. J. Nucl. Med., 1973, 14, (4), 191 [Google Scholar]
  17. Litterst C. L., Gran T. E., Dedrick R. L., Leroy A. F., and Guarino A. M. Cancer Res., 1976, 36, (7), 2340 [Google Scholar]
  18. Smith P. H. S., and Taylor D. M. J. Nucl. Med., 1974, 15, (5), 349 [Google Scholar]
  19. Hill J. M., Loeb E., MacLellan A., Hill N. O., Khan A., and King J. J. Cancer Chemother. Rep., 1975, 59, (3), 647 [Google Scholar]
  20. DeConti R. C., Toftness B. R., Lange R. C., and Creasey W. A. Cancer Res., 1973, 33, (6), 1310 [Google Scholar]
  21. Bannister S. J., Sternson L. A., Repta A. J., and James G. W. Clin. Chem., 1977, 23, (12), 2258 [Google Scholar]
  22. Malerbi B. W., and Wiltshaw E. London
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