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Volume 31, Issue 3
  • ISSN: 0032-1400


Since the original demonstrations of homogeneous organometallic catalysis under mild conditions in the 1960s there has been much progress. A central focus for development has been asymmetric synthesis, through the use of optically active ligands. Chiral chelating biphosphines have played a key role in these advances, which have led to: asymmetric hydrogenation as a route to amino-acids and Vitamin E precursors, kinetic resolution in directed hydrogenation, asymmetric isomerisation of olefins in a route to citronellol, and asymmetric catalytic C-C bond formation. This review highlights recent developments.


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  1. Crabtree R.H. Acc. Chem. Res., 1979, 12, (9), 331 [Google Scholar]
  2. Trost B. M., and Verhoeven T. R. “Comprehensive Organometallic Chemistry”, [Google Scholar]
  3. Wilkinson G., Stone F. G. A., and Abel E. W. ed. Pergamon, Oxford, 1982, 8, p. 799
  4. Auburn P. R., Mackenzie P. B., and Bosnich B. J. Am. Chem. Soc., 1985, 107, (7), 2033; [Google Scholar]
  5. Mackenzie P. B., Whelan J., and Bosnich B. ibid., 1985, 107, (7), 2046
  6. Hayashi T., Yamamoto A., Hagihara T., and Ito Y. Tetrahedron Lett., 1986, 27, (2), 191; [Google Scholar]
  7. Hayashi T., Yamamoto A., and Ito Y. J. Chem. Soc., Chem. Commun., 1986, (14), 1090; [Google Scholar]
  8. Hayashi T., Yamamoto A., and Ito Y. Chem. Lett., 1987, (1), 177 [Google Scholar]
  9. Hayashi T., and Kumada M. For a general discussion see “Asymmetric Synthesis”, [Google Scholar]
  10. Morrison J. D. ed. Academic Press, 1985, 5, p. 147 ff.
  11. Hayashi T., Konishi M., Okamoto Y., Kabeta K., and Kumada M. J. Org. Chem., 1986, 51, (20), 3772 [Google Scholar]
  12. Kagan H. B., and Dang T. P. J. Am. Chem. Soc., 1972, 94, (18), 6429 [Google Scholar]
  13. Landis C. R., and Halpern J. J. Am. Chem. Soc., 1987, 109, (6), 1746; [Google Scholar]
  14. Brown J. M., and Maddox P. J. J. Chem. Soc., Chem. Commun., 1987, in press; [Google Scholar]
  15. Brown J. M., and Chaloner P. A. “Homogeneous Catalysis with Metal Phosphine Complexes”, [Google Scholar]
  16. ed. Pignolet L. H. Plenum Press, New York, 1983, p. 137
  17. Brown J. M. Angew. Chem. Int. Ed. Engl., 1987, 26, (3), 190, and references therein [Google Scholar]
  18. Miyashita A., Yasuda A., Takaya H., Toriumi K., Ito T., Souchi T., and Noyori R. (a)J. Am. Chem. Soc., 1980, 102, (27), 7932; [Google Scholar]
  19. Ikariya T., Ishii Y., Kawano H., Awai T., Saburi M., Yoshikawa S., and Akutagawa S. (b)J. Chem. Soc., Chem. Commun., 1985, (13), 922; [Google Scholar]
  20. Noyori R., Ohta M., Hsiao Y., Kitamura M., Ohta T., and Takaya H. J. Am. Chem. Soc., 1986, 108, (22), 7117; [Google Scholar]
  21. Takaya H., Ohta T., Sayo N., Kumobayashi H., Akutagawa S., Inoue S., Kasahara I., and Noyori R. (c)J. Am. Chem. Soc., 1987, 109, (5), 1596 [Google Scholar]
  22. Tani K., Yamagata T., Akutagawa S., Kumobayashi H., Taketomi T., Takaya H., Miyashita A., Noyori R., and Otsuka S. J. Am. Chem. Soc., 1984, 106, (18), 5208 [Google Scholar]
  23. Consiglio G., Pino P., Flowers L. I., and Pittman C. U. J. Chem. Soc., Chem. Commun., 1983, (11), 612; [Google Scholar]
  24. Pittman C. U., Kawabata Y., and Flowers L. I. ibid., 1982, (9), 473

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