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1887
Volume 39, Issue 1
  • ISSN: 0032-1400

Abstract

Photodynamic therapy is a clinical technique employing the combination of light, oxygen and a sensitising compound to induce the photochemical destruction of unwanted tissue. Light therapy has been known for some time, but it was not until the earlier part of this century that the first clinical work was performed using sensitisers and light. More recently a sensitising compound of a complex mixture of porphyrins has been tested on various cancers, and been awarded regulatory approval for its use. In this paper the synthesis and properties of some novel and easily prepared water soluble ruthenium phthalocyanine complexes are reported. One of these complexes, JM 2929, has been extensively studied and has photosensitising properties which when used in combination with light and oxygen in vitro and in vivo during photodynamic therapy displays remarkable cytotoxic effects.

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1995-01-01
2024-06-14
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  • Article Type: Research Article
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