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Volume 39, Issue 4
  • ISSN: 0032-1400


Recent discoveries in the biological sciences have revealed that nitric oxide has a number of important physiological functions and is also implicated in a number of diseases. This realisation has provided a stimulus for nitric oxide related drug research and development. In this review new work aimed at the development of potential therapeutic use of ruthenium compounds, particularly ruthenium(III) polyaminocarboxylate, JM1226, is presented and discussed in the context of the chemistry and biology of nitric oxide. Based on these studies, prospects for the further development of JM1226 appear promising.


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