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Volume 40, Issue 4
  • ISSN: 0032-1400


The hydration of nitriles to amides is one of the basic transformations in organic chemistry However, it is not generally appreciated how difficult this transformation is to carry out efficiently since amides themselves undergo further hydrolysis to the acid. While nicotinamide and acrylamide are usually manufactured from the corresponding nitriles using metallic copper heterogeneous catalysts, applications in the fine chemicals industry are rare. Now, the use of a new platinum-containing homogeneous catalyst applicable to complex organic nitriles containing sensitive functional groups will create an opportunity for nitrile hydration in the fine chemical and pharmaceutical industries.


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  1. Rabinovich B. S., and Winkler C A. Can. J. Res., 1942, 20B, 221; [Google Scholar]
  2. O’Connor C J. Quart. Rev., 1970, 24, 553 [Google Scholar]
  3. Radziszweski B. Ber. Duch. Chem. Ges., 1885, 18, 355 [Google Scholar]
  4. Wiberg K.B. J. Am. Chem. Soc., 1953, 75, 3961 [Google Scholar]
  5. Katritzky A. R., Pilarski B., and Urogdi L. Synthesis, 1989, 949 and references therein [Google Scholar]
  6. Suh M. P., Oh K. Y., Lee J. W., and Bae Y. Y. J. Am. Chem. Soc., 1996, 118, 777 [Google Scholar]
  7. Michelin R. A., Mozzon M., and Bertani R. Coord. Chem. Rev., 1996, 147, 299; [Google Scholar]
  8. Hay R. W., Wilkinson G., Gillard R. D., and McCleverry J. A. Comprehensive Co-ordination Chemistry” eds. Pergamon, Oxford, 1987, Vol. 6, pp. 411485, espec. p. 449 [Google Scholar]
  9. Diamond S. E., Grant B., Tom G. M., and Taube H. Tetrahedron Lett., 1974, 4025 [Google Scholar]
  10. Buckingham D. A., Morris P., Sargeson A. M., and Zanella A. Inorg. Chem., 1977, 16, 1910 [Google Scholar]
  11. Chin J., and Kjm J. H. Angetv. Chem. Int. Ed Engl., 1990, 29, 523; [Google Scholar]
  12. Kim J. H., Britten J., and Chin J. J. Am. Chem. Soc., 1993, 115, 3618 [Google Scholar]
  13. McKenzie C J., and Robson R. J. Chem. Soc., Chem. Commun., 1988, 112 [Google Scholar]
  14. Pudovik A. N., Sudakova T. M., and Evstaf’ev G. I. J. Gen. Chem., USSR, (Engl. Trans.), 1974, 44, 2371 [Google Scholar]
  15. Ghaffar T., and Parkins A. W. Tetrahedron Lett., 1995, 36, 8657 [Google Scholar]
  16. Roundhill D. M., Sperline R. P., and Beaulieu W B. Co-ord. Chem. Rev., 1978, 26, 263 [Google Scholar]
  17. van Leeuwen P. W. N. M., Roobeek C R, Frjns J. H. G., and Orpen A. G. Organometallics, 1990, 9, 1211 [Google Scholar]
  18. British Patent Appl., 9506389.7; 1995 [Google Scholar]
  19. Jensen CM., and Trogler W C J. Am. Chem. Soc., 1986, 108, 723 [Google Scholar]
  20. Villain G., Constant G., Gaset A., and Kalck P. J. Mol. Catal., 1980, 7, 355 [Google Scholar]
  21. Yoshida T., Matsuda T., Okano T., Kitani T., and Otsuka S. J. Am. Chem. Soc, 1979, 101, 2027 [Google Scholar]
  22. Stevenson M., Heyes S. J., Ghaffar T., and Parkins A. W. Manuscript in preparation [Google Scholar]
  23. Thorn D. L., and Calabrese J. C J. Organomet. Chem., 1984, 272, 283 [Google Scholar]
  24. Gadreau C., Foucoud A., and Merot P. Synthesis, 1981, 73 [Google Scholar]
  25. Menger F. M. Acc Chem. Res., 1985, 18, 128; [Google Scholar]
  26. Kirby A. J. Angew. Chem. Int. Ed. Engl, 1994, 33, 551; [Google Scholar]
  27. Breslow R. Ace. Chem. Res., 1995, 28, 146 [Google Scholar]
  28. Akisanya J., and Parkins A. W. King’s College London, unpublished work
  29. Boyd D. R., and Byrne B. E. Queen’s University of Belfast, unpublished data

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