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oa 3-Hydroxycarboplatin, a Simple Carboplatin Derivative Endowed with an Improved Toxicological Profile
- Source: Platinum Metals Review, Volume 56, Issue 4, Oct 2012, p. 248 - 256
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- 01 Jan 2012
Abstract
3-Hydroxycarboplatin, a simple carboplatin derivative, was synthesised using a novel method, characterised and evaluated for its anticancer activity in vitro and in vivo. It shows comparable antitumour activity to that of carboplatin but has much lower toxicity particularly with respect to myelosuppression, revealing great potential for development as a new antitumour platinum drug to replace carboplatin.
© Johnson Matthey