Asymmetric Transfer Hydrogenation in Water with Platinum Group Metal Catalysts: Rapid reactions and high enantioselectivities achieved for carbonyl bond reduction

By Xiaofeng Wu; Chao Wang; Jianliang Xiao

doi:10.1595/147106709X481372

ISSN: 0032-1400

oa Asymmetric Transfer Hydrogenation in Water with Platinum Group Metal Catalysts

Rapid reactions and high enantioselectivities achieved for carbonyl bond reduction
Authors: By Xiaofeng Wu¹, Chao Wang¹ and Jianliang Xiao¹
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¹ Liverpool Centre for Materials and CatalysisDepartment of ChemistryThe University of LiverpoolCrown Street, Liverpool L69 7ZDUK
Source: Platinum Metals Review, Volume 54, Issue 1, Jan 2010, p. 3 - 19
DOI: https://doi.org/10.1595/147106709X481372
- Published online: 01 Jan 2016

Abstract

Asymmetric transfer hydrogenation (ATH) is the reduction of prochiral compounds with a hydrogen donor other than hydrogen gas in the presence of a chiral catalyst. The asymmetric reduction of a wide variety of ketone and aldehyde substrates has been carried out in water using catalysts based on complexes of ruthenium(II), rhodium(III) and iridium(III), affording fast reaction rates and good enantioselectivities without the use of organic solvents and with easy separation of catalyst and product. For ATH of ketones, the Rh(III) complexes appear to perform better than the Ru(II) and Ir(III) complexes in terms of activity, enantioselectivity and substrate scope. However, their performance varies with the choice of ligands, and simple Ir(III)-diamine complexes were found to be excellent catalysts for the reduction of aldehydes.

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Asymmetric Transfer Hydrogenation in Water with Platinum Group Metal Catalysts

Platinum Metals Review 54, 3 (2010); https://doi.org/10.1595/147106709X481372

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oa Asymmetric Transfer Hydrogenation in Water with Platinum Group Metal Catalysts

Rapid reactions and high enantioselectivities achieved for carbonyl bond reduction

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