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1887
Volume 63, Issue 3
  • ISSN: 2056-5135

Abstract

The formulation and delivery of the biologically active ingredients (AIs) (for example, agrochemicals and active pharmaceutical ingredients (APIs)) is an inherently interdisciplinary area of research and development. In this short review we discuss the evolution of AI and API delivery systems towards smart stimuli-responsive formulations with precisely controlled delivery for specific applications. We also highlight a few examples of such systems using AIs from Johnson Matthey’s controlled substance and API portfolio.

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2019-01-01
2024-11-22
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References

  1. A. G. Atanasov, B. Waltenberger, E.-M. Pferschy-Wenzig, T. Linder, C. Wawrosch, P. Uhrin, V. Temml, L. Wang, S. Schwaiger, E. H. Heiss, J. M. Rollinger, D. Schuster, J. M. Breuss, V. Bochkov, M. D. Mihovilovic, B. Kopp, R. Bauer, V. M. Dirsch, H. Stuppner, Biotechnol. Adv., 2015, 33, (8), 1582 LINK https://doi.org/10.1016/j.biotechadv.2015.08.001 [Google Scholar]
  2. A. C. Anselmo, S. Mitragotri, J. Control. Release, 2014, 190, 15 LINK https://doi.org/10.1016/j.jconrel.2014.03.053 [Google Scholar]
  3. S. J. Dixon, B. R. Stockwell, Nature Chem. Biol., 2010, 6, (5), 318 LINK https://doi.org/10.1038/nchembio.353 [Google Scholar]
  4. W. Sneader, “Drug Discovery: A History”, John Wiley and Sons Ltd, Chichester, UK, 2005, 468 pp LINK https://doi.org/10.1002/0470015535 [Google Scholar]
  5. D. R. Kirsch, ‘Therapeutic Drug Development and Human Clinical Trials’, in “Biotechnology Entrepreneurship: Starting, Managing, and Leading Biotech Companies”, ed. C. Shimasaki, Elsevier Inc, Waltham, USA, 2014, pp. 315330 LINK https://doi.org/10.1016/b978-0-12-404730-3.00023-3 [Google Scholar]
  6. M. A. Turner, M. Catapano, S. Hirschfeld, C. Giaquinto, Adv. Drug Deliv. Rev., 2014, 73, 2 LINK https://doi.org/10.1016/j.addr.2014.02.003 [Google Scholar]
  7. G. Tiwari, R. Tiwari, B. Sriwastawa, L. Bhati, S. Pandey, P. Pandey, S. Bannerjee, Int. J. Pharm. Investig., 2012, 2, (1), 2 LINK https://doi.org/10.4103/2230-973x.96920 [Google Scholar]
  8. P. M. Sinha, G. Valco, S. Sharma, X. Liu, M. Ferrari, Nanotechnol., 2004, 15, (10), S585 LINK https://doi.org/10.1088/0957-4484/15/10/015 [Google Scholar]
  9. L. Lutgens, J. van der Zee, M. Pijls-Johannesma, D. F. M. De Haas-Kock, J. Buijsen, G. A. P. G. van Mastrigt, G. Lammering, D. K. M. De Ruysscher, P. Lambin, Cochrane Database Syst. Rev., 2010, (3), CD 006377 LINK https://doi.org/10.1002/14651858.cd006377.pub3 [Google Scholar]
  10. A. Lieder, M. K. Khan, B. M. Lippert, Cochrane Database Syst. Rev., 2014, (6), CD009810 LINK https://doi.org/10.1002/14651858.cd009810.pub2 [Google Scholar]
  11. P. Tharyan, C. E. Adams, Cochrane Database Syst. Rev., 2005, (2), CD000076 LINK https://doi.org/10.1002/14651858.CD000076.pub2 [Google Scholar]
  12. J. G. Woolcock, R. M. Grivell, J. M. Dodd, Cochrane Database Syst. Rev., 2014, (11), CD011371 LINK https://doi.org/10.1002/14651858.cd011371 [Google Scholar]
  13. A. L. Shada, L. T. Dengel, G. R. Petroni, M. E. Smolkin, S. Acton, C. L. Slingluff, J. Surg. Res., 2013, 182, (1), e9 LINK https://doi.org/10.1016/j.jss.2012.09.022 [Google Scholar]
  14. J. Khandare, T. Minko, Prog. Polym. Sci., 2006, 31, (4), 359 LINK https://doi.org/10.1016/j.progpolymsci.2005.09.004 [Google Scholar]
  15. A. Vashist, A. Vashist, Y. K. Gupta, S. Ahmad, J. Mater. Chem. B, 2014, 2, (2), 147 LINK https://doi.org/10.1039/c3tb21016b [Google Scholar]
  16. A. R. Maity, D. Stepensky, Mol. Pharmaceutics, 2016, 13, (1), 1 LINK https://doi.org/10.1021/acs.molpharmaceut.5b00697 [Google Scholar]
  17. C. Dhand, M. P. Prabhakaran, R. W. Beuerman, R. Lakshminarayanan, N. Dwivedi, S. Ramakrishna, RSC Adv., 2014, 4, (62), 32673 LINK https://doi.org/10.1039/c4ra02861a [Google Scholar]
  18. R. C. Toon, E. C. Preedy, P. Prokopovich, Eurasian Chem. Tech. J., 2012, 14, (4), 271 LINK https://doi.org/10.18321/ectj124 [Google Scholar]
  19. M. W. Walter, Nat. Prod. Rep., 2002, 19, (3), 278 LINK https://doi.org/10.1039/b100919m [Google Scholar]
  20. R. K. Verma, B. Mishra, S. Garg, Drug Dev. Ind. Pharm., 2000, 26, (7), 695 LINK https://doi.org/10.1081/ddc-100101287 [Google Scholar]
  21. K. Park, J. Control. Release, 2014, 190, 3 LINK https://doi.org/10.1016/j.jconrel.2014.03.054 [Google Scholar]
  22. K. Park, Mol. Pharmaceutics, 2016, 13, (7), 2143 LINK https://doi.org/10.1021/acs.molpharmaceut.6b00015 [Google Scholar]
  23. K. Park, J. Control. Release, 2016, 240, 2 LINK https://doi.org/10.1016/j.jconrel.2015.10.048 [Google Scholar]
  24. D. P. van Kammen, J. P. Docherty, S. R. Marder, J. N. Rayner, W. E. Bunney Jr, Arch. Gen. Psychiatry, 1982, 39, (3), 275 LINK https://doi.org/10.1001/archpsyc.1982.04290030017003 [Google Scholar]
  25. Y. H. Yun, B. K. Lee, K. Park, J. Control. Release, 2015, 219, 2 LINK https://doi.org/10.1016/j.jconrel.2015.10.005 [Google Scholar]
  26. ‘Highlights of Prescribing Information – SEROQUEL® (Quetiapine Fumarate) Tablets, for Oral Use’, Reference ID 4060088, AstraZeneca, Wilmington, USA, February, 2017: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020639s065lbl.pdf (Accessed on 31st May 2019) [Google Scholar]
  27. C. Figueroa, M. Brecher, J. E. Hamer-Maansson, H. Winter, Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 2009, 33, (2), 199 LINK https://doi.org/10.1016/j.pnpbp.2008.09.026 [Google Scholar]
  28. W. R. Good, A. J. Piraino, J. Control. Release, 1990, 11, (1–3), 315 LINK https://doi.org/10.1016/0168-3659(90)90144-i [Google Scholar]
  29. H. Zhong, G. Chan, Y. Hu, H. Hu, D. Ouyang, Pharmaceutics, 2018, 10, (4), 263 LINK https://doi.org/10.3390/pharmaceutics10040263 [Google Scholar]
  30. R. Langer, “Biodegradable Polymers as Drug Delivery Systems”, eds. M. Chasin, Drugs and the Pharmaceutical Sciences, Vol. 45, Marcel Dekker Inc, New York, USA, 1990, 347 pp [Google Scholar]
  31. L. Shieh, J. Tamada, Y. Tabata, A. Domb, R. Langer, J. Control. Release, 1994, 29, (1–2), 73 LINK https://doi.org/10.1016/0168-3659(94)90123-6 [Google Scholar]
  32. J. Kost, R. Langer, Adv. Drug Deliv. Rev., 2012, 64, 327 LINK https://doi.org/10.1016/j.addr.2012.09.014 [Google Scholar]
  33. K. E. Uhrich, S. M. Cannizzaro, R. S. Langer, K. M. Shakesheff, Chem. Rev., 1999, 99, (11), 3181 LINK https://doi.org/10.1021/cr940351u [Google Scholar]
  34. A. S. Hoffman, J. Control. Release, 2008, 132, (3), 153 LINK https://doi.org/10.1016/j.jconrel.2008.08.012 [Google Scholar]
  35. F. Dosio, S. Arpicco, B. Stella, E. Fattal, Adv. Drug Deliv. Rev., 2016, 97, 204 LINK https://doi.org/10.1016/j.addr.2015.11.011 [Google Scholar]
  36. J. M. Harris, R. B. Chess, Nat. Rev. Drug Discov., 2003, 2, (3), 214 LINK https://doi.org/10.1038/nrd1033 [Google Scholar]
  37. R. B. Greenwald, Puerto Rico Health Sci. J., 2002, 21, (2), 113 LINK http://prhsj.rcm.upr.edu/index.php/prhsj/article/download/885/604 [Google Scholar]
  38. K.-S. Lee, D. S. Kim, B. S. Kim, Biotechnol. Bioprocess Eng., 2007, 12, (2), 152 LINK https://doi.org/10.1007/bf03028642 [Google Scholar]
  39. H. Seong, T. K. An, G. Khang, S.-U. Choi, C. O. Lee, H. B. Lee, Int. J. Pharm., 2003, 251, (1–2), 1 LINK https://doi.org/10.1016/s0378-5173(02)00543-4 [Google Scholar]
  40. C. Barnard, Johnson Matthey Technol. Rev., 2017, 61, (1), 52 LINK https://www.technology.matthey.com/article/61/1/52-59/ [Google Scholar]
  41. S. Dhar, F. X. Gu, R. Langer, O. C. Farokhzad, S. J. Lippard, Proc. Natl. Acad. Sci., 2008, 105, (45), 17356 LINK https://doi.org/10.1073/pnas.0809154105 [Google Scholar]
  42. A. Srivastava, T. Yadav, S. Sharma, A. Nayak, A. A. Kumari, N. Mishra, J. Biosci. Med., 2016, 04, (01), 69 LINK https://doi.org/10.4236/jbm.2016.41009 [Google Scholar]
  43. Z. Zhao, C. Ding, Y. Wang, H. Tan, J. Li, Biomater. Sci., 2019, 7, (4), 1643 LINK https://doi.org/10.1039/c8bm01640b [Google Scholar]
  44. L. M. Ensign, R. Cone, J. Hanes, Adv. Drug Deliv. Rev., 2012, 64, (6), 557 LINK https://doi.org/10.1016/j.addr.2011.12.009 [Google Scholar]
  45. Z. Liu, S. Wang, M. Hu, Y. Chen, G. G. Z. Zhang, L. Liu, W. R. Porter, ‘Oral Absorption Basics: Pathways, Physico-chemical and Biological Factors Affecting Absorption’, in “Developing Solid Oral Dosage Forms – Pharmaceutical Theory and Practice”, eds. Y. Qiu, Elsevier Inc, Burlington, USA, 2009, pp. 265288 LINK https://doi.org/10.1016/b978-0-444-53242-8.00011-4 [Google Scholar]
  46. G. P. Carino, J. S. Jacob, E. Mathiowitz, J. Control. Release, 2000, 65, (1–2), 261 LINK https://doi.org/10.1016/s0168-3659(99)00247-3 [Google Scholar]
  47. R. I. Henkin, Nutrition, 2010, 26, (1), 33 LINK https://doi.org/10.1016/j.nut.2009.08.001 [Google Scholar]
  48. S. Mutalik Venkatesh, N. Udupa, Indian Drugs, 2002, 39, (6), 305 [Google Scholar]
  49. K. S. Paudel, M. Milewski, C. L. Swadley, N. K. Brogden, P. Ghosh, A. L. Stinchcomb, Ther. Deliv., 2010, 1, (1), 109 LINK https://doi.org/10.4155/tde.10.16 [Google Scholar]
  50. A. C. Parrott, Psychopharmacol., 1986, 89, (3), 347 LINK https://doi.org/10.1007/bf00174373 [Google Scholar]
  51. J. M. Moon, B. J. Chun, J. Emerg. Med., 2011, 40, (1), 37 LINK https://doi.org/10.1016/j.jemermed.2007.10.075 [Google Scholar]
  52. W. R. Good, M. S. Powers, P. Campbell, L. Schenkel, J. Control. Release, 1985, 2, 89 LINK https://doi.org/10.1016/0168-3659(85)90035-5 [Google Scholar]
  53. B. Godin, E. Touitou, Adv. Drug Deliv. Rev., 2007, 59, (11), 1152 LINK https://doi.org/10.1016/j.addr.2007.07.004 [Google Scholar]
  54. P.-T. Ko, I.-C. Lee, M.-C. Chen, S.-W. Tsai, J. Taiwan Inst. Chem. Eng., 2015, 51, 1 LINK https://doi.org/10.1016/j.jtice.2015.01.003 [Google Scholar]
  55. Y.-C. Kim, J.-H. Park, M. R. Prausnitz, Adv. Drug Deliv. Rev., 2012, 64, (14), 1547 LINK https://doi.org/10.1016/j.addr.2012.04.005 [Google Scholar]
  56. S. P. Sullivan, D. G. Koutsonanos, M. del Pilar Martin, J. W. Lee, V. Zarnitsyn, S.-O. Choi, N. Murthy, R. W. Compans, I. Skountzou, M. R. Prausnitz, Nature Med., 2010, 16, (8), 915 LINK https://doi.org/10.1038/nm.2182 [Google Scholar]
  57. S.-P. Khor, A. Hsu, Curr. Clin. Pharmacol., 2007, 2, (3), 234 LINK https://doi.org/10.2174/157488407781668802 [Google Scholar]
  58. N. Goonoo, A. Bhaw-Luximon, R. Ujoodha, A. Jhugroo, G. K. Hulse, D. Jhurry, J. Control. Release, 2014, 183, 154 LINK https://doi.org/10.1016/j.jconrel.2014.03.046 [Google Scholar]
  59. M. F. Armaly, K. R. Rao, Investig. Ophthalmol. Vis. Sci., 1973, 12, (7), 491 LINK https://iovs.arvojournals.org/article.aspx?articleid=2158352 [Google Scholar]
  60. K. P. Sampath Kumar, D. Bhowmik, G. Harish, S. Duraivel, B. Pragathi kumar, Pharma Innov., 2013, 1, (12), 1 LINK http://www.thepharmajournal.com/vol1Issue12/Issue_feb_2013/1.1.pdf [Google Scholar]
  61. H. Brem, Biomater., 1990, 11, (9), 699 LINK https://doi.org/10.1016/0142-9612(90)90030-t [Google Scholar]
  62. C. Regnier-Delplace, O. Thillaye du Boullay, F. Siepmann, B. Martin-Vaca, N. Degrave, P. Demonchaux, O. Jentzer, D. Bourissou, J. Siepmann, Int. J. Pharm., 2013, 443, (1–2), 68 LINK https://doi.org/10.1016/j.ijpharm.2013.01.008 [Google Scholar]
  63. G. Yang, J. Liu, Y. Wu, L. Feng, Z. Liu, Coord. Chem. Rev., 2016, 320–321, 100 LINK https://doi.org/10.1016/j.ccr.2016.04.004 [Google Scholar]
  64. R. Tong, H. D. Hemmati, R. Langer, D. S. Kohane, J. Am. Chem. Soc., 2012, 134, (21), 8848 LINK https://doi.org/10.1021/ja211888a [Google Scholar]
  65. C. Alvarez-Lorenzo, L. Bromberg, A. Concheiro, Photochem. Photobiol., 2009, 85, (4), 848 LINK https://doi.org/10.1111/j.1751-1097.2008.00530.x [Google Scholar]
  66. P. Yang, S. Gai, J. Lin, Chem. Soc. Rev., 2012, 41, (9), 3679 LINK https://doi.org/10.1039/c2cs15308d [Google Scholar]
  67. S. Mura, J. Nicolas, P. Couvreur, Nature Mater., 2013, 12, (11), 991 LINK https://doi.org/10.1038/nmat3776 [Google Scholar]
  68. R. Deckers, C. T. W. Moonen, J. Control. Release, 2010, 148, (1), 25 LINK https://doi.org/10.1016/j.jconrel.2010.07.117 [Google Scholar]
  69. D. J. Schmidt, J. S. Moskowitz, P. T. Hammond, Chem. Mater., 2010, 22, (23), 6416 LINK https://doi.org/10.1021/cm102578j [Google Scholar]
  70. P. Lambin, J. Zindler, B. G. L. Vanneste, L. Van De Voorde, D. Eekers, I. Compter, K. M. Panth, J. Peerlings, R. T. H. M. Larue, T. M. Deist, A. Jochems, T. Lustberg, J. van Soest, E. E. C. de Jong, A. J. G. Even, B. Reymen, N. Rekers, M. van Gisbergen, E. Roelofs, S. Carvalho, R. T. H. Leijenaar, C. M. L. Zegers, M. Jacobs, J. van Timmeren, P. Brouwers, J. A. Lal, L. Dubois, A. Yaromina, E. J. Van Limbergen, M. Berbee, W. van Elmpt, C. Oberije, B. Ramaekers, A. Dekker, L. J. Boersma, F. Hoebers, K. M. Smits, A. J. Berlanga, S. Walsh, Adv. Drug Deliv. Rev., 2017, 109, 131 LINK https://doi.org/10.1016/j.addr.2016.01.006 [Google Scholar]
  71. C. Alvarez-Lorenzo, A. Concheiro, Chem. Commun., 2014, 50, (58), 7743 LINK https://doi.org/10.1039/c4cc01429d [Google Scholar]
  72. S. Erkeçoğlu, A. D. Sezer, S. Bucak, ‘Smart Delivery Systems with Shape Memory and Self-Folding Polymers’, in “Smart Drug Delivery Systems”, ed. A. D. Sezer, InTech, London, UK, 2016, 29 pp LINK https://doi.org/10.5772/62199 [Google Scholar]
  73. G. I. Peterson, A. V Dobrynin, M. L. Becker, Adv. Healthcare Mater., 2017, 6, (21), 1700694 LINK https://doi.org/10.1002/adhm.201700694 [Google Scholar]
  74. C. Wischke, A. T. Neffe, A. Lendlein, ‘Controlled Drug Release from Biodegradable Shape-Memory Polymers’, in “Shape-Memory Polymers”, ed. A. Lendlein, Advances in Polymer Science, Vol. 226, Springer-Verlag Berlin Heidelberg, Dordrecht, The Netherlands, 2010, pp. 177205 LINK https://doi.org/10.1007/978-3-642-12359-7_29 [Google Scholar]
  75. J. G. Hardy, M. Palma, S. J. Wind, M. J. Biggs, Adv. Mater., 2016, 28, (27), 5717 LINK https://doi.org/10.1002/adma.201505417 [Google Scholar]
  76. C. S. Linsley, B. M. Wu, Ther. Deliv., 2017, 8, (2), 89 LINK https://doi.org/10.4155/tde-2016-0060 [Google Scholar]
  77. A. E. O’Connor, W. M. Gallagher, A. T. Byrne, Photochem. Photobiol., 2009, 85, (5), 1053 LINK https://doi.org/10.1111/j.1751-1097.2009.00585.x [Google Scholar]
  78. M. S. Kim, S. L. Diamond, Bioorg. Med. Chem. Lett., 2006, 16, (15), 4007 LINK https://doi.org/10.1016/j.bmcl.2006.05.013 [Google Scholar]
  79. A. M. L. Hossion, M. Bio, G. Nkepang, S. G. Awuah, Y. You, ACS Med. Chem. Lett., 2013, 4, (1), 124 LINK https://doi.org/10.1021/ml3003617 [Google Scholar]
  80. R.-M. Ion, ‘Porphyrins and Phthalocyanines: Photosensitizers and Photocatalysts’, in, “Phthalocyanines and Some Current Applications”, ed. Y. Yilmaz, InTech, London, UK, 2017, pp. 189221 LINK https://doi.org/10.5772/intechopen.68654 [Google Scholar]
  81. Y. Shamay, L. Adar, G. Ashkenasy, A. David, Biomater., 2011, 32, (5), 1377 LINK https://doi.org/10.1016/j.biomaterials.2010.10.029 [Google Scholar]
  82. H. J. Cho, M. Chung, M. S. Shim, J. Ind. Eng. Chem., 2015, 31, 15 LINK https://doi.org/10.1016/j.jiec.2015.07.016 [Google Scholar]
  83. V. A. N. Huu, J. Luo, J. Zhu, J. Zhu, S. Patel, A. Boone, E. Mahmoud, C. McFearin, J. Olejniczak, C. de Gracia Lux, J. Lux, N. Fomina, M. Huynh, K. Zhang, A. Almutairi, J. Control. Release, 2015, 200, 71 LINK https://doi.org/10.1016/j.jconrel.2015.01.001 [Google Scholar]
  84. I. Tomatsu, K. Peng, A. Kros, Adv. Drug Deliv. Rev., 2011, 63, (14–15), 1257 LINK https://doi.org/10.1016/j.addr.2011.06.009 [Google Scholar]
  85. E. R. Ruskowitz, C. A. DeForest, Nature Rev. Mater., 2018, 3, (2), 17087 LINK https://doi.org/10.1038/natrevmats.2017.87 [Google Scholar]
  86. B. Zinger, L. L. Miller, J. Am. Chem. Soc., 1984, 106, (22), 6861 LINK https://doi.org/10.1021/ja00334a076 [Google Scholar]
  87. S. Sirivisoot, R. Pareta, T. J. Webster, Nanotechnol., 2011, 22, (8), 85101 LINK https://doi.org/10.1088/0957-4484/22/8/085101 [Google Scholar]
  88. Y. Shen, M. Wan, Synth. Met., 1998, 96, (2), 127 LINK https://doi.org/10.1016/s0379-6779(98)00076-9 [Google Scholar]
  89. J. Pokki, O. Ergeneman, K. M. Sivaraman, B. Özkale, M. A. Zeeshan, T. Lühmann, B. J. Nelson, S. Pané, Nanoscale, 2012, 4, (10), 3083 LINK https://doi.org/10.1039/c2nr30192j [Google Scholar]
  90. L.-M. Huang, C.-H. Chen, T.-C. Wen, Electrochim. Acta, 2006, 51, (26), 5858 LINK https://doi.org/10.1016/j.electacta.2006.03.031 [Google Scholar]
  91. A. Peramo, M. G. Urbanchek, S. A. Spanninga, L. K. Povlich, P. Cederna, D. C. Martin, Tissue Eng. Part A, 2008, 14, (3), 423 LINK https://doi.org/10.1089/tea.2007.0123 [Google Scholar]
  92. K. F. A. Clancy, J. G. Hardy, Curr. Pharm. Des., 2017, 23, (24), 3614 LINK https://doi.org/10.2174/1381612823666170710124137 [Google Scholar]
  93. J. G. Hardy, J. Y. Lee, C. E. Schmidt, Curr. Opin. Biotechnol., 2013, 24, (5), 847 LINK https://doi.org/10.1016/j.copbio.2013.03.011 [Google Scholar]
  94. J. G. Hardy, M. N. Amend, S. Geissler, V. M. Lynch, C. E. Schmidt, J. Mater. Chem. B, 2015, 3, (25), 5005 LINK https://doi.org/10.1039/c5tb00106d [Google Scholar]
  95. J. G. Hardy, D. J. Mouser, N. Arroyo-Currás, S. Geissler, J. K. Chow, L. Nguy, J. M. Kim, C. E. Schmidt, J. Mater. Chem. B, 2014, 2, (39), 6809 LINK https://doi.org/10.1039/c4tb00355a [Google Scholar]
  96. F. Li, Y. Zhu, Y. Wang, Microporous Mesoporous Mater., 2014, 200, 46 LINK https://doi.org/10.1016/j.micromeso.2014.07.060 [Google Scholar]
  97. R. Cheng, F. Meng, C. Deng, H.-A. Klok, Z. Zhong, Biomater., 2013, 34, (14), 3647 LINK https://doi.org/10.1016/j.biomaterials.2013.01.084 [Google Scholar]
  98. M. S. Strozyk, S. Carregal-Romero, M. Henriksen-Lacey, M. Brust, L. M. Liz-Marzán, Chem. Mater., 2017, 29, (5), 2303 LINK https://doi.org/10.1021/acs.chemmater.6b05471 [Google Scholar]
  99. W. Zhao, J.-S. Wei, P. Zhang, J. Chen, J.-L. Kong, L.-H. Sun, H.-M. Xiong, H. Möhwald, ACS Appl. Mater. Interfaces, 2017, 9, (22), 18474 LINK https://doi.org/10.1021/acsami.7b02542 [Google Scholar]
  100. X. Chen, Q. Zhang, J. Li, M. Yang, N. Zhao, F.-J. Xu, ACS Nano, 2018, 12, (6), 5646 LINK https://doi.org/10.1021/acsnano.8b01440 [Google Scholar]
  101. W. Zhang, J. Dai, G. Zhang, Y. Zhang, S. Li, D. Nie, Nanoscale Res. Lett., 2018, 13, 379 LINK https://doi.org/10.1186/s11671-018-2787-8 [Google Scholar]
  102. D. Nikjoo, A. Z. Aroguz, J. Appl. Polym. Sci., 2017, 134, (33), 45143 LINK https://doi.org/10.1002/app.45143 [Google Scholar]
  103. H. H. Tønnesen, J. Karlsen, Drug Dev. Ind. Pharm., 2002, 28, (6), 621 LINK https://doi.org/10.1081/ddc-120003853 [Google Scholar]
  104. A. H. Morris, R. S. Mahal, J. Udell, M. Wu, T. R. Kyriakides, Adv. Healthcare Mater., 2017, 6, (19), 1700370 LINK https://doi.org/10.1002/adhm.201700370 [Google Scholar]
  105. X. Lu, S. Liu, X. Yang, M. Han, K. Sun, J. Pharm. Biomed. Anal., 2019, 164, 181 LINK https://doi.org/10.1016/j.jpba.2018.10.043 [Google Scholar]
  106. T.-L. Hwang, Y.-K. Lin, C.-H. Chi, T.-H. Huang, J.-Y. Fang, J. Pharm. Sci., 2009, 98, (10), 3735 LINK https://doi.org/10.1002/jps.21687 [Google Scholar]
  107. D. Mittal, A. Ali, S. Md, S. Baboota, J. K. Sahni, J. Ali, Drug Deliv., 2014, 21, (2), 75 LINK https://doi.org/10.3109/10717544.2013.838713 [Google Scholar]
  108. S. W. Stein, C. G. Thiel, J. Aerosol Med. Pulm. Drug Deliv., 2017, 30, (1), 20 LINK https://doi.org/10.1089/jamp.2016.1297 [Google Scholar]
  109. Z. Y. Pessetto, B. Chen, H. Alturkmani, S. Hyter, C. A. Flynn, M. Baltezor, Y. Ma, H. G. Rosenthal, K. A. Neville, S. J. Weir, A. J. Butte, A. K. Godwin, Oncotarget, 2017, 8, (3), 4079 LINK https://doi.org/10.18632/oncotarget.13385 [Google Scholar]
  110. A. A. Aref, Curr. Opin. Ophthalmol., 2017, 28, (2), 169 LINK https://10.1097/ICU.0000000000000334 [Google Scholar]
  111. E. Nuxoll, Adv. Drug Deliv. Rev., 2013, 65, (11–12), 1611 LINK https://doi.org/110.1097/ICU.0000000000000334 [Google Scholar]
  112. A. B. Fleming, W. M. Saltzman, Clin. Pharmacokinet., 2002, 41, (6), 403LINK https://doi.org/10.2165/00003088-200241060-00002 [Google Scholar]
  113. E. R. Gillies, J. M. J. Frechet, Drug Discov. Today, 2005, 10, (1), 35 LINK https://doi.org/10.1016/s1359-6446(04)03276-3 [Google Scholar]
  114. R. C. Huxford, J. D. Rocca, W. Lin, Curr. Opin. Chem. Biol., 2010, 14, (2), 262 LINK https://doi.org/10.1016/j.cbpa.2009.12.012 [Google Scholar]
  115. I. Naldi, M. Taranta, L. Gherardini, G. Pelosi, F. Viglione, S. Grimaldi, L. Pani, C. Cinti, PLoS One, 2014, 9, (5), e98101 LINK https://doi.org/10.1371/journal.pone.0098101 [Google Scholar]
  116. H. N. E. Stevens, C. G. Wilson, P. G. Welling, M. Bakhshaee, J. S. Binns, A. C. Perkins, M. Frier, E. P. Blackshaw, M. W. Frame, D. J. Nichols, M. J. Humphrey, S. R. Wicks, Int. J. Pharm., 2002, 236, (1–2), 27 LINK https://doi.org/10.1016/s0378-5173(02)00012-1 [Google Scholar]
  117. T. Daniels, N. Mills, P. Whitaker, Cochrane Database Syst. Rev., 2013, (4), CD007639 LINK https://doi.org/10.1002/14651858.cd007639.pub2 [Google Scholar]
  118. P. T. Wong, S. K. Choi, Chem. Rev., 2015, 115, (9), 3388 LINK https://doi.org/10.1021/cr5004634 [Google Scholar]
  119. T. M. Allen, P. R. Cullis, Adv. Drug Deliv. Rev., 2013, 65, (1), 36 LINK https://doi.org/10.1016/j.addr.2012.09.037 [Google Scholar]
  120. M. H. De Vries, J. Van Harten, P. Van Bemmel, M. Raghoebar, Biopharm. Drug Dispos., 1993, 14, (4), 291 LINK https://doi.org/10.1002/bdd.2510140403 [Google Scholar]
  121. K. E. Thummel, Adv. Drug Deliv. Rev., 1997, 27, (2–3), 99 LINK https://doi.org/10.1016/s0169-409x(97)00039-2 [Google Scholar]
  122. M. Lodhi, A. Dubey, R. Narayan, P. Prabhu, S. Priya, Int. J. Pharm. Investig., 2013, 3, (1), 47 LINK https://doi.org/10.4103/2230-973x.108963 [Google Scholar]
  123. T. Gomathi, C. Govindarajan, M. H. Rose, P. N. Sudha, P. K. M. Imran, J. Venkatesan, S.-K. Kim, Int. J. Pharm., 2014, 468, (1–2), 214 LINK https://doi.org/10.1016/j.ijpharm.2014.04.026 [Google Scholar]
  124. Y. Miao, J. Sun, G. Chen, R. Lili, P. Ouyang, Drug Dev. Ind. Pharm., 2016, 42, (8), 1234 LINK https://doi.org/10.3109/03639045.2015.1118496 [Google Scholar]
  125. B. Lubamba, J. Lebacq, P. Lebecque, R. Vanbever, A. Leonard, P. Wallemacq, T. Leal, Am. J. Respir. Crit. Care Med., 2009, 179, (11), 1022 LINK https://doi.org/10.1164/rccm.200901-0049oc [Google Scholar]
  126. S. S. Satav, S. Bhat, S. Thayumanavan, Biomacromolecules, 2010, 11, (7), 1735 LINK https://doi.org/10.1021/bm1005454 [Google Scholar]
  127. K. Rostamizadeh, M. Vahedpour, S. Bozorgi, Int. J. Pharm., 2012, 424, (1–2), 67 LINK https://doi.org/10.1016/j.ijpharm.2011.12.054 [Google Scholar]
  128. J. Tang, J. M. Li, G. Li, H. T. Zhang, L. Wang, D. Li, J. S. Ding, Int. J. Nanomedicine, 2017, 12, 6687 LINK https://doi.org/10.2147/ijn.s140569 [Google Scholar]
  129. M. J. Balunas, A. D. Kinghorn, Life Sci., 2005, 78, (5), 431 LINK https://doi.org/10.1016/j.lfs.2005.09.012 [Google Scholar]
  130. L. R. Ranganath, A. M. Milan, A. T. Hughes, J. J. Dutton, R. Fitzgerald, M. C. Briggs, H. Bygott, E. E. Psarelli, T. F. Cox, J. A. Gallagher, J. C. Jarvis, C. van Kan, A. K. Hall, D. Laan, B. Olsson, J. Szamosi, M. Rudebeck, T. Kullenberg, A. Cronlund, L. Svensson, C. Junestrand, H. Ayoob, O. G. Timmis, N. Sireau, K.-H. Le Quan Sang, F. Genovese, D. Braconi, A. Santucci, M. Nemethova, A. Zatkova, J. McCaffrey, P. Christensen, G. Ross, R. Imrich, J. Rovensky, Ann. Rheum. Dis., 2014, 75, (2), 362 LINK https://doi.org/10.1136/annrheumdis-2014-206033 [Google Scholar]
  131. R. J. Patel, D. M. Witt, J. J. Saseen, D. J. Tillman, D. S. Wilkinson, Pharmacotherapy, 2000, 20, (10), 1159 LINK https://doi.org/10.1592/phco.20.15.1159.34585 [Google Scholar]
  132. R. Trivedi, E. F. Redente, A. Thakur, D. W. H. Riches, U. B. Kompella, Nanotechnology, 2012, 23, (50), 505101 LINK https://doi.org/10.1088/0957-4484/23/50/505101 [Google Scholar]
  133. T. Ji, J. Lang, J. Wang, R. Cai, Y. Zhang, F. Qi, L. Zhang, X. Zhao, W. Wu, J. Hao, Z. Qin, Y. Zhao, G. Nie, ACS Nano, 2017, 11, (9), 8668 LINK https://doi.org/10.1021/acsnano.7b01026 [Google Scholar]
  134. A. Detappe, H. Nguyen, C. Mathieu, Y. Jiang, M. Agius, O. Zavidij, B. Berrios, Y. Shen, J. A. Johnson, P. Peter Ghoroghchian, I. M. Ghobria, Blood, 2018, 132, Suppl. 1, 4681 LINK https://doi.org/10.1182/blood-2018-99-116517 [Google Scholar]
  135. M. A. Mastrodicasa, C. A. Droege, A. M. Mulhall, N. E. Ernst, R. J. Panos, M. A. Zafar, Expert Opin. Investig. Drugs, 2017, 26, (2), 161 LINK https://doi.org/10.1080/13543784.2017.1276167 [Google Scholar]
  136. É. Y. Suzuki, M. I. Amaro, G. S. de Almeida, L. M. Cabral, A. M. Healy, V. P. de Sousa, Int. J. Pharm., 2018, 550, (1–2), 89 LINK https://doi.org/10.1016/j.ijpharm.2018.08.035 [Google Scholar]
  137. W. Park, J. Chen, S. Cho, S. Park, A. C. Larson, K. Na, D.-H. Kim, ACS Appl. Mater. Interfaces, 2016, 8, (20), 12711 LINK https://doi.org/10.1021/acsami.6b03505 [Google Scholar]
  138. D. H. Kim, M.-D. Kim, C.-W. Choi, C.-W. Chung, S. H. Ha, C. H. Kim, Y.-H. Shim, Y.-I. Jeong, D. H. Kang, Nanoscale Res. Lett., 2012, 7, 91 LINK https://doi.org/10.1186/1556-276x-7-91 [Google Scholar]
  139. A. Grillone, E. R. Riva, A. Mondini, C. Forte, L. Calucci, C. Innocenti, C. de Julian Fernandez, V. Cappello, M. Gemmi, S. Moscato, F. Ronca, R. Sacco, V. Mattoli, G. Ciofani, Adv. Healthc. Mater., 2015, 4, (11), 1681 LINK https://doi.org/10.1002/adhm.201500235 [Google Scholar]
  140. P. Denis, Expert Opin. Pharmacother., 2011, 12, (3), 463 LINK https://doi.org/10.1517/14656566.2011.551007 [Google Scholar]
  141. F. K. Tanno, S. Sakuma, Y. Masaoka, M. Kataoka, T. Kozaki, R. Kamaguchi, Y. Ikeda, H. Kokubo, S. Yamashita, J. Pharm. Sci., 2008, 97, (12), 5341 LINK https://doi.org/10.1002/jps.21382 [Google Scholar]
  142. R. Balint, N. J. Cassidy, S. H. Cartmell, Acta Biomater., 2014, 10, (6), 2341 LINK https://doi.org/10.1016/j.actbio.2014.02.015 [Google Scholar]
  143. D. Brambilla, P. Luciani, J.-C. Leroux, J. Control. Release, 2014, 190, 9 LINK https://doi.org/10.1016/j.jconrel.2014.03.056 [Google Scholar]
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