Skip to content
1887
  1. Home
  2. A-Z Publications
  3. Johnson Matthey Technology Review
  4. Volume 67, Issue 3
  5. Article
Volume 67, Issue 3
  • ISSN: 2056-5135
file format pdf download PDF

Abstract

What’s the long- and short-term prognosis for palladium in organic synthesis, the key platinum group metal (pgm) for transition metal-based catalysis used today by the fine chemicals industries? Are these processes green and sustainable? Are they environmentally respectful of the metals, especially the pgms, so essential to modern day society? Are non-pgm ‘earth abundant’ metals an attractive alternative? Where does the up-and-coming area of chemoenzymatic catalysis, which combines chemo- and biocatalysis in one-pot processes in water, fit into the future of drug syntheses? And what about agricultural targets also being made that include palladium catalysis? These and related timely topics are discussed in this Perspective.

© Johnson Matthey
Loading

Article metrics loading...

/content/journals/10.1595/205651323X16698159435916
2022-11-30
2024-12-26
Loading full text...

Full text loading...

/deliver/fulltext/jmtr/67/3/Lipshutz_16a_Imp.html?itemId=/content/journals/10.1595/205651323X16698159435916&mimeType=html&fmt=ahah

References

  1. ‘Endangered Elements’, American Chemical Society, September, 2019, Washington, USA LINK https://www.acs.org/content/acs/en/greenchemistry/research-innovation/endangered-elements.html [Google Scholar]
  2. ‘Palladium Prices – Interactive Historical Chart’, MacroTrends, Seattle, USA:https://www.macrotrends.net/2542/palladium-prices-historical-chart-data (Accessed on 28th July, 2022) [Google Scholar]
  3. M. J. Goldfogel, X. Guo, J. L. Meléndez Matos, J. A. Gurak, M. V. Joannou, W. B. Moffat, E. M. Simmons, S. R. Wisniewski, Org. Process Res. Dev., 2022, 26, (3), 785 LINK https://technology.matthey.com/article/67/3/285-289/ [Google Scholar]
  4. S. Handa, E. D. Slack, B. H. Lipshutz, Angew. Chem. Int. Ed., 2015, 54, (41), 11994 LINK https://doi.org/10.1002/anie.201505136 [Google Scholar]
  5. ‘ICH Q3D Elemental Impurities – Scientific Guideline’, European Medicines Agency, Amsterdam, The Netherlands:https://www.ema.europa.eu/en/ich-q3d-elemental-impurities (Accessed on 28th July 2022) [Google Scholar]
  6. A. M. Thayer, ‘Trace Metals Debate’, Chemical Engineering News, Washington, DC, USA, August, 2013 LINK https://cen.acs.org/articles/91/i33/Trace-Metals-Debate.html [Google Scholar]
  7. ‘Committee for Human Medicinal Products (CHMP): Guideline on the Specification Limits for Residues of Metal Catalysts’, Doc. Ref. CPMP/SWP/QWP/4446/00 corr., European Medicines Agency, Amsterdam, The Netherlands, January, 2007, 32 pp LINK https://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003587.pdf [Google Scholar]
  8. E. Schofield, Johnson Matthey Technol. Rev., 2023, 67, (3), 285 LINK https://technology.matthey.com/article/67/3/???-???/ [Google Scholar]
  9. S. Pithani, M. Malmgren, C.-J. Aurell, G. Nikitidis, S. D. Friis, Org. Process Res. Dev., 2019, 23, (8), 1752 LINK https://doi.org/10.1021/acs.oprd.9b00237 [Google Scholar]
  10. G. L. Beutner, E. M. Simmons, S. Ayers, C. Y. Bemis, M. J. Goldfogel, C. L. Joe, J. Marshall, S. R. Wisniewski, J. Org. Chem., 2021, 86, (15), 10380 LINK https://doi.org/10.1021/acs.joc.1c01073 [Google Scholar]
  11. B. H. Lipshutz, J. Org. Chem., 2017, 82, (6), 2806 LINK https://doi.org/10.1021/acs.joc.7b00010 [Google Scholar]
  12. B. H. Lipshutz, Curr. Opin. Green Sus. Chem., 2018, 11, 1 LINK https://doi.org/10.1016/j.cogsc.2017.10.004 [Google Scholar]
  13. B. H. Lipshutz, S. Ghorai, A. R. Abela, R. Moser, T. Nishikata, C. Duplais, A. Krasovskiy, R. D. Gaston, R. C. Gadwood, J. Org. Chem., 2011, 76, (11), 4379 LINK https://doi.org/10.1021/jo101974u [Google Scholar]
  14. J. Brals, J. D. Smith, F. Ibrahim, F. Gallou, S. Handa, ACS Catal., 2017, 7, 7245 LINK https://doi.org/10.1021/acscatal.7b02663 [Google Scholar]
  15. Y. Zhang, B. Zhu, Y. Zheng, S. Huang, J. Organomet. Chem., 2022, 965–966, 122321 LINK https://doi.org/10.1016/j.jorganchem.2022.122321 [Google Scholar]
  16. N. Miyaura, A. Suzuki, J. Chem. Soc. Chem. Commun., 1979, (19), 866 LINK https://doi.org/10.1039/c39790000866 [Google Scholar]
  17. S. Handa, M. P. Andersson, F. Gallou, J. Reilly, B. H. Lipshutz, Angew. Chem. Int. Ed., 2016, 55, (16), 4914 LINK https://doi.org/10.1002/anie.201510570 [Google Scholar]
  18. N. Akporji, R. R. Thakore, M. Cortes-Clerget, J. Andersen, E. Landstrom, D. H. Aue, F. Gallou, B. H. Lipshutz, Chem. Sci., 2020, 11, (20), 5205 LINK https://doi.org/10.1039/d0sc00968g [Google Scholar]
  19. R. R. Thakore, B. S. Takale, F. Gallou, J. Reilly, B. H. Lipshutz, ACS Catal., 2019, 9, (12), 11647 LINK https://doi.org/10.1021/acscatal.9b04204 [Google Scholar]
  20. B. Jin, F. Gallou, J. Reilly, B. H. Lipshutz, Chem. Sci., 2019, 10, (12), 3481 LINK https://doi.org/10.1039/C8SC05618H [Google Scholar]
  21. B. S. Takale, R. R. Thakore, G. Casotti, X. Li, F. Gallou, B. H. Lipshutz, Angew. Chem. Int. Ed., 2021, 60, (8), 4158 LINK https://doi.org/10.1002/anie.202014141 [Google Scholar]
  22. H. Pang, Y. Hu, J. Yu, F. Gallou, B. H. Lipshutz, J. Am. Chem. Soc., 2021, 143, (9), 3373 LINK https://doi.org/10.1021/jacs.0c11484 [Google Scholar]
  23. Y. Hu, M. J. Wong, B. H. Lipshutz, Angew. Chem. Int. Ed., 2022, 61, (39), e202209784 LINK https://doi.org/10.1002/anie.202209784 [Google Scholar]
  24. Y. Zhang, B. S. Takale, F. Gallou, J. Reilly, B. H. Lipshutz, Chem. Sci., 2019, 10, (45), 10556 LINK https://doi.org/10.1039/c9sc03710a [Google Scholar]
  25. R. R. Thakore, K. S. Iyer, B. H. Lipshutz, Curr. Opin. Green Sustain. Chem., 2021, 31, 100493 LINK https://doi.org/10.1016/j.cogsc.2021.100493 [Google Scholar]
  26. J. R. A. Kincaid, M. J. Wong, N. Akporji, F. Gallou, D. M. Fialho, B. H. Lipshutz, J. Am. Chem. Soc., 2023, 145, (7), 4266 LINK https://doi.org/10.1021/jacs.2c13444 [Google Scholar]
  27. J. Becker, C. Manske, S. Randl, Curr. Opin. Green Sustain. Chem., 2022, 33, 100562 LINK https://doi.org/10.1016/j.cogsc.2021.100562 [Google Scholar]
  28. L. Bering, J. Thompson, J. Micklefield, Trends Chem., 2022, 4, (5), 392 LINK https://doi.org/10.1016/j.trechm.2022.02.008 [Google Scholar]
  29. F. H. Arnold, Angew. Chem. Int. Ed., 2018, 57, (16), 4143 LINK https://doi.org/10.1002/anie.201708408 [Google Scholar]
  30. V. Singhania, M. Cortes-Clerget, J. Dussart-Gautheret, B. Akkachairin, J. Yu, N. Akporji, F. Gallou, B. H. Lipshutz, Chem. Sci., 2022, 13, (5), 1440 LINK https://doi.org/10.1039/d1sc05660c [Google Scholar]
  31. M. Cortes-Clerget, N. Akporji, J. Zhou, F. Gao, P. Guo, M. Parmentier, F. Gallou, J.-Y. Berthon, B. H. Lipshutz, Nat. Commun., 2019, 10, 2169 LINK https://doi.org/10.1038/s41467-019-09751-4 [Google Scholar]
  32. ‘Value of Palladium Exports from Russia from 2018 to 2021 (in Million US Dollars)’, Statista Inc, New York, USA, May, 2022 LINK https://www.statista.com/statistics/1295821/palladium-exports-russia/ [Google Scholar]
  33. S. Handa, Y. Wang, F. Gallou, B. H. Lipshutz, Science, 2015, 349, (6252), 1087 LINK https://doi.org/10.1126/science.aac6936 [Google Scholar]
  34. S. K. Ritter, ‘A More Natural Approach to Catalysts’, Chemical Engineering News, Washington, DC, USA, February, 2017 LINK https://cen.acs.org/articles/95/i8/natural-approach-catalysts.html [Google Scholar]
  35. L. K. Boerner, ‘Metal-Free? The Mistake that Chemists Seem Doomed to Repeat’, Chemical Engineering News, Washington, DC, USA, February, 2022 LINK https://cen.acs.org/synthesis/catalysis/metal-free-mistake-chemists-doomed-repeat-impurities-contamination-Suzuki-coupling/100/i6 [Google Scholar]
  36. B. H. Lipshutz, J. C. Caravez, K. S. Iyer, Curr. Opin. Green Sustain. Chem., 2022, 38, 100686 LINK https://doi.org/10.1016/j.cogsc.2022.100686 [Google Scholar]
  37. B. H. Lipshutz, Synlett, 2021, 32, (16), 1588 LINK https://doi.org/10.1055/s-0040-1706027 [Google Scholar]
/content/journals/10.1595/205651323X16698159435916
Loading
On the Sustainability of Palladium in Organic Synthesis: A Perspective
Johnson Matthey Technology Review 67, 278 (2023); https://doi.org/10.1595/205651323X16698159435916
/content/journals/10.1595/205651323X16698159435916
/content/journals/10.1595/205651323X16698159435916
Loading

Data & Media loading...

  • Article Type: Research Article

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test