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Volume 64, Issue 4
  • ISSN: 2056-5135


The purpose of this study was to devise an antibacterial treatment for footwear insock leathers. Orange oil-loaded chitosan microparticles were utilised for this purpose. Emulsion formulations with different ratios were prepared, and from these formulations microparticles were manufactured using a spray drying technique. Microparticles obtained in this way were applied to the insock leathers using a finishing process. Successful encapsulation was confirmed by ultraviolet-visible (UV-vis) spectrophotometry, Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) techniques. The microparticles exhibited highly spheroid shape with a size range of 3–5 μm. Microparticle encapsulation efficiencies ranged from 79.41% ± 3.36% to 86.60% ± 1.13%. After performing microbiological tests and release studies on the insock leathers, it was determined that the prepared microparticles are able to perform core material delivery. Also, successful microparticle application resulted in these leathers acquiring antibacterial properties. The products and process are biodegradable, nontoxic and biocompatible.


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  1. Özkan V. K., Uzun M. T., and Gündoğan M. T. J. Fungus, 2018, 9, (2), 182 LINK [Google Scholar]
  2. Yalçın H., and Özkalp B. ‘Importance of Body Hygiene and New Developments in Wound Care’,4th National Sterilization Disinfection Congress, 20th–24th April, 2005, Samsun, Turkey, Bilimsel Tıp Publishing House, Ankara, Turkey, 287–308 LINK [Google Scholar]
  3. Majidnia Z., Idris A., and Valipour P. J. Teknol., 2013, 60, (1), 5 LINK [Google Scholar]
  4. Velmurugan P., Cho M., Lee S.-M., Park J.-H., Bae S., and Oh B.-T. Carbohydr. Polym., 2014, 106, 319 LINK [Google Scholar]
  5. Sánchez-Navarro M. M., Pérez-Limiñana M. A., Cuesta-Garrote N., Maestre-López M. I., Bertazzo M., Martínez-Sánchez M. A., Arán-Aís F., ‘Latest Developments in Antimicrobial Functional Materials for Footwear’, in “Microbial Pathogens and Strategies for Combating Them: Science, Technology and Education”, ed. and Méndez-Vilas A. Vol. 1, Formatex, New York City, USA, 2013, pp. 102–113 [Google Scholar]
  6. Tülek Z. ‘A Research Over Side Industry Products in the Shoe Manufacturing’, Master Thesis, Social Science Institute, Istanbul Arel University, Turkey, 2016, 126 pp [Google Scholar]
  7. Gohel M., Parikh R. K., Nagori S. A., Gandhi A. V., Shroff M. S., Patel P. K., Gandhi C. S., Patel V., Bhagat N. Y., Poptani S. D., Kharadi S. R., Pandya R., and Patel T. C. Pharma. Rev., 2009, 7, (5), 1 [Google Scholar]
  8. Estevinho B. N., Rocha F., Santos L., and Alves A. Trends Food Sci. Technol., 2013, 31, (2), 138 LINK [Google Scholar]
  9. Santos D., Maurício A. C., Sencadas V., Santos J. D., Fernandes M. H., Gomes P. S., ‘Spray Drying: An Overview’, in “Biomaterials: Physics and Chemistry”, ed. and Pignatello R. InTechOpen, London, UK, 2018, pp. 9–35 LINK [Google Scholar]
  10. Tomazelli Júnior O., Kuhn F., Padilha P. J. M., Vicente L. R. M., Costa S. W., Boligon A. A., Scapinello J., Nesi C. N., Dal Magro J., and Castellví S. L. Braz. J. Biol., 2018, 78, (2), 311 LINK [Google Scholar]
  11. Li Y., Ai L., Yokoyama W., Shoemaker C. F., Wei D., Ma J., and Zhong F. J. Agric. Food Chem., 2013, 61, (13), 3311 LINK [Google Scholar]
  12. Gönülşen I., Sariişik M., Erkan G., and Okur S. Tekst. ve Mühendis, 2016, 23, (101), 21 LINK [Google Scholar]
  13. Rossi W., Bonet-Aracil M., Bou-Belda E., Gisbert-Payá J., Wilson K., and Roldo L. IOP Conf. Ser. Mater. Sci. Eng., 2017, 254, (2), 022007 LINK [Google Scholar]
  14. Velmurugan P., Ganeshan V., Nishter N. F., and Jonnalagadda R. R. Surf. Interfac., 2017, 9, 124 LINK [Google Scholar]
  15. Fernandes I. P., Amaral J. S., Pinto V., Ferreira M. J., and Barreiro M. F. Carbohydr. Polym., 2013, 98, (1), 1229 LINK [Google Scholar]
  16. Sánchez-Navarro M. M., Pérez-Limiñana M. A., Arán-Aís F., and Orgilés-Barceló C. Polymer Int., 2015, 64, (10), 1458 LINK [Google Scholar]
  17. Torres-Alvarez C., Núñez González A., Rodríguez J., Castillo S., Leos-Rivas C., and Báez-González J. G. CyTA-J. Food, 2017, 15, (1), 129 LINK [Google Scholar]
  18. Suwannateep N., Wanichwecharungruang S., Haag S. F., Devahastin S., Groth N., Fluhr J. W., Lademann J., and Meinke M. C. Eur. J. Pharm. Biopharm., 2012, 82, (3), 485 LINK [Google Scholar]
  19. Kleban M., Weisser J., Koch F., and Schwaiger W. Bayer Corp, ‘Leather Finished with Scent-Containing Microcapsules’, US Patent Appl. 2002/198,392
  20. Yalcin F., Karavana H. A., Rencber S., and Karavana S. Y. J. Am. Leather Chem. Assoc., 2020, 115, (3), 79 LINK [Google Scholar]
  21. Caputo G. M., Cavanagh P. R., Ulbrecht J. S., Gibbons G. W., and Karchmer A. W. N. Engl. J. Med., 1994, 331, (13), 854 LINK [Google Scholar]
  22. Calhoun J. H., Overgaard K. A., Stevens C. M., Dowling J. P. F., and Mader J. T. Adv. Skin Wound Care, 2002, 15, (1), 31 LINK [Google Scholar]
  23. Örmen B., Türker N., Vardar I., Coşkun N.A., Kaptan F., Ural S., El S., and Türker M. Turkish J. Infect., 2007, 21, (2), 65 LINK [Google Scholar]
  24. Yaşa İ., Lkhagvajav N., Koizhaiganova M., Çelik E., and Sarı Ö. World J. Microbiol. Biotechnol., 2012, 28, (7), 2531 LINK [Google Scholar]
  25. Karavana H. A., Rencber S., Karavana S. Y., and Yalcin F. ‘Encapsulated Chlorhexidine Digluconate Usage on the Diabetic Footwear Lining Leathers’, 6th International Conference on Advanced Materials and Systems (ICAMS), 20th–22nd October, 2016, Bucharest, Romania, CERTEX, Bucharest, Romania, 257–262 LINK [Google Scholar]
  26. Soottitantawat A., Yoshii H., Furuta T., Ohgawara M., Forssell P., Partanen R., Poutanen K., and Linko P. J. Agric. Food Chem., 2004, 52, (5), 1269 LINK [Google Scholar]
  27. Javid A., Raza Z. A., Hussain T., and Rehman A. J. Microencapsul., 2014, 31, (5), 461 LINK [Google Scholar]
  28. Mi F.-L., Sung H.-W., Shyu S.-S., Su C.-C., and Peng C.-K. Polymer, 2003, 44, (21), 6521 LINK [Google Scholar]
  29. Bhumkar D. R., and Pokharkar V. B. AAPS PharmSciTech, 2006, 7, (2), E138 LINK [Google Scholar]
  30. Yoksan R., Jirawutthiwongchai J., and Arpo K. Coll. Surf. B: Biointer., 2010, 76, (1), 292 LINK [Google Scholar]
  31. Jingou J., Shilei H., Weiqi L., Danjun W., Tengfei W., and Yi X. Coll. Surf. B: Biointer., 2011, 83, (1), 103 LINK [Google Scholar]
  32. Keawchaoon L., and Yoksan R. Coll. Surf. B: Biointer., 2011, 84, (1), 163 LINK [Google Scholar]
  33. Hosseini S. F., Zandi M., Rezaei M., and Farahmandghavi F. Carbohydr. Polym., 2013, 95, (1), 50 LINK [Google Scholar]
  34. Chang A. K. T., Frias R. R., Alvarez L. V, Bigol U. G., and Guzman J. P. M. D. Biocatal. Agric. Biotechnol., 2019, 17, 189 LINK [Google Scholar]
  35. Cava D., Lagarón J. M., López-Rubio A., Catalá R., and Gavara R. Polym. Test., 2004, 23, (5), 551 LINK [Google Scholar]
  36. Li D., Wu H., Huang W., Guo L., and Dou H. Eur. J. Lipid Sci. Technol., 2018, 120, (9), 1700521 LINK [Google Scholar]
  37. Boughendjioua H., and Djeddi S. Am. J. Opt. Photonics, 2017, 5, (3), 30 LINK [Google Scholar]
  38. Şenyiğit T., Sonvico F., Barbieri S., Özer Ö., Santi P., and Colombo P. J. Control. Release, 2010, 142, (3), 368 LINK [Google Scholar]
  39. Tanrıverdi S. T., and Özer Ö. Eur. J. Pharm. Sci., 2013, 48, (4–5), 628 LINK [Google Scholar]
  40. Hariharan S., Bhardwaj V., Bala I., Sitterberg J., Bakowsky U., and Ravi Kumar M. N. V. Pharm. Res., 2006, 23, (1), 184 LINK [Google Scholar]

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